GDB1 - bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase (Saccharomyces cerevisiae S288C)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-26
Description
Enables 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Involved in glycogen catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase).
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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