PXA1 - ATP-binding cassette long-chain fatty acid transporter PXA1 (Saccharomyces cerevisiae S288C)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Enables ATPase-coupled transmembrane transporter activity. Involved in ATP transport and fatty acid transport. Is active in peroxisomal membrane. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in Zellweger syndrome; adrenoleukodystrophy; and congenital bile acid synthesis defect 5. Orthologous to several human genes including ABCD1 (ATP binding cassette subfamily D member 1).
- LPI1
- PAL1
- PAT2
- SSH2
Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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