An official website of the United States government

PXA1 - ATP-binding cassette long-chain fatty acid transporter PXA1 (Saccharomyces cerevisiae S288C)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-02-01
Description
Enables ATPase-coupled transmembrane transporter activity. Involved in ATP transport and fatty acid transport. Is active in peroxisomal membrane. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in Zellweger syndrome; adrenoleukodystrophy; and congenital bile acid synthesis defect 5. Orthologous to several human genes including ABCD1 (ATP binding cassette subfamily D member 1).

1 Names and Identifiers

1.1 Synonyms

  • LPI1
  • PAL1
  • PAT2
  • SSH2

1.2 Other Identifiers

1.2.1 Alliance Gene ID

1.2.2 SGD ID

1.2.3 VEuPathDB ID

1.2.4 Wikidata

2 Proteins

2.1 Protein Function

Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix.

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 Gene-Chemical Co-Occurrences in Literature

6.3 Gene-Gene Co-Occurrences in Literature

6.4 Gene-Disease Co-Occurrences in Literature

7 Patents

8 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  6. STRING: functional protein association networks
  7. NCBI Gene Expression Omnibus (GEO)
  8. Saccharomyces Genome Database (SGD)
    LICENSE
    SGD operates under the Creative Commons Attribution 4.0 International license (CC BY 4.0).
    https://sites.google.com/view/yeastgenome-help/about
  9. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  10. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  11. Wikidata
  12. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
CONTENTS