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GTR1 - Rag GTPase GTR1 (Saccharomyces cerevisiae S288C)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-20
Description
Enables GTPase activity. Involved in several processes, including DNA-templated transcription; negative regulation of metabolic process; and positive regulation of TORC1 signaling. Acts upstream of or within cellular response to oxidative stress. Located in fungal-type vacuole membrane; late endosome membrane; and nucleus. Part of Gtr1-Gtr2 GTPase complex and Ragulator complex. Orthologous to several human genes including RRAGB (Ras related GTP binding B).

1 Names and Identifiers

1.1 Other Identifiers

1.1.1 Alliance Gene ID

1.1.2 Enzyme Commission (EC) Number

1.1.3 GlyCosmos Gene

1.1.4 SGD ID

1.1.5 VEuPathDB ID

1.1.6 Wikidata

2 Proteins

2.1 Protein Function

GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (PMID: 26510498, PMID: 28993463, PMID: 32801125). Also required for TORC1 inactivation during nitrogen starvation (PMID: 28993463). Required for intracellular sorting of GAP1 out of the endosome (PMID: 16732272). Functionally associated with the inorganic phosphate transporter PHO84, and may be involved in regulating its function or localization (PMID: 1620108).

2.2 Protein 3D Structures

2.2.1 PDB Structures

2.2.2 NCBI Protein Structures

2.2.3 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 Gene-Chemical Co-Occurrences in Literature

6.3 Gene-Gene Co-Occurrences in Literature

6.4 Gene-Disease Co-Occurrences in Literature

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  6. STRING: functional protein association networks
  7. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  8. NCBI Gene Expression Omnibus (GEO)
  9. NCBI Structure
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  10. RCSB Protein Data Bank (RCSB PDB)
    LICENSE
    Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.
    https://www.rcsb.org/pages/policies
  11. Saccharomyces Genome Database (SGD)
    LICENSE
    SGD operates under the Creative Commons Attribution 4.0 International license (CC BY 4.0).
    https://sites.google.com/view/yeastgenome-help/about
  12. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  13. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  14. Wikidata
  15. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  16. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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