MTM1 - Mtm1p (Saccharomyces cerevisiae S288C)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Enables pyridoxal phosphate binding activity. Involved in intracellular iron ion homeostasis and pyridoxal phosphate transport. Located in mitochondrion. Orthologous to human SLC25A39 (solute carrier family 25 member 39) and SLC25A40 (solute carrier family 25 member 40).
Involved in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner. Responds to calorie restriction (CR) strength.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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