WDR73 - WD repeat domain 73 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
The protein encoded by the WDR73 gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Involved in cytoplasmic microtubule organization; negative regulation of apoptotic process; and nucleus organization. Located in cleavage furrow; cytosol; and spindle pole. Implicated in Galloway-Mowat syndrome 1.
- GAMOS
- GAMOS1
- HSPC264
- WD repeat-containing protein 73
- FLJ00296 protein
May play a role in the regulation of microtubule organization and dynamics (PMID: 25466283).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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