GPR61 - G protein-coupled receptor 61 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by the GPR61 gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
Enables arrestin family protein binding activity. Involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane. Part of receptor complex.
- BALGR
- GPCR3
- G-protein coupled receptor 61
- biogenic amine receptor-like G-protein coupled receptor
- biogenic amine receptor-like GPCR
- probable G-protein coupled receptor 61
Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PMID: 28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PMID: 28827538). May be involved in the regulation of food intake and body weight (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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