Ncoa2 - nuclear receptor coactivator 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables DNA polymerase binding activity and nuclear receptor binding activity. Involved in several processes, including positive regulation of female receptivity; positive regulation of glucocorticoid receptor signaling pathway; and response to estradiol. Located in dendritic spine. Used to study polycystic ovary syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2).
- GRIP-1
- Grip1
- Tif2
- NCoA-2
- glucocorticoid receptor interacting protein 1
- transcriptional intermediary factor 2
- Glucocorticoid Receptor-Interacting Protein 1
- Steroid Receptor Coactivator SRC2
- Steroid Receptor Coactivator-2
- Transcription Intermediary Factor 2
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- STRING: functional protein association networks
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