CVP2 - DNAse I-like superfamily protein (thale cress)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-30
Description
Encodes an inositol polyphosphate 5' phosphatase (5PTase) that is required for the proper recruitment of cells into developing vascular tissue in leaves and cotyledons. It is most similar to Type I 5PTases that are known to cleave a phosphate from IP3 or IP4. cvp2 mutants have elevated levels of IP3 and are hypersensitive to ABA in seed germination assays.
- COTYLEDON VASCULAR PATTERN 2
- T25N20.12
- T25N20_12
Has phosphatase activity toward PtdIns(4,5)P2 and PtdIns(3,4,5)P3 (PMID: 19473324). Required for the patterning of procambium and during the differentiation of vascular tissues. Acts before the acquisition of preprocambial identity. Seems to be also involved in the abscisic acid (ABA) signaling pathway (PMID: 10559439, PMID: 15100402). Acts redundantly with CVL1 for maintaining vascular continuity (PMID: 19363154, PMID: 25813544). Regulates phosphoinositide-dependent VAN3 localization (PMID: 19473324).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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