GCH - GTP cyclohydrolase II (thale cress)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-31
Description
encodes GTP cyclohydrolase II that can functionally complement E. coli mutant deficient in this gene. It also has 3,4-dihydroxy-2-butanone-4-phosphate synthase activity which makes it a bifunctional enzyme involved in the formation of the pyrimidine and of the carbohydrate from GTP and ribulose-5-phosphate, respectively
- ARABIDOPSIS THALIANA GTP CYCLOHYDROLASE II
- ATGCH
- ATRIBA1
- Arabidopsis thaliana riboflavin A1
- GTP CYCLOHYDROLASE II
- GTP cyclohydrolase II
- RED FLUORESCENT IN DARKNESS 1
- RFD1
- RIBA1
- riboflavin A1
- 7,8-Dihydroneopterintriphosphate Synthetase
- GTP 8-Formylhydrolase
- GTP Cyclohydrolase I
- GTP Cyclohydrolase II
- GTP Dihydrolase
- GTP Ring-Opening Enzyme
Involved in riboflavin biosynthesis. Catalyzes both the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate and the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. RIBA2 and RIBA3 together are not able to complement the loss of function of RIBA1.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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