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GCH - GTP cyclohydrolase II (thale cress)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2024-12-31
Description
encodes GTP cyclohydrolase II that can functionally complement E. coli mutant deficient in this gene. It also has 3,4-dihydroxy-2-butanone-4-phosphate synthase activity which makes it a bifunctional enzyme involved in the formation of the pyrimidine and of the carbohydrate from GTP and ribulose-5-phosphate, respectively

1 Names and Identifiers

1.1 Synonyms

  • ARABIDOPSIS THALIANA GTP CYCLOHYDROLASE II
  • ATGCH
  • ATRIBA1
  • Arabidopsis thaliana riboflavin A1
  • GTP CYCLOHYDROLASE II
  • GTP cyclohydrolase II
  • RED FLUORESCENT IN DARKNESS 1
  • RFD1
  • RIBA1
  • riboflavin A1

1.1.1 MeSH Entry Terms

  • 7,8-Dihydroneopterintriphosphate Synthetase
  • GTP 8-Formylhydrolase
  • GTP Cyclohydrolase I
  • GTP Cyclohydrolase II
  • GTP Dihydrolase
  • GTP Ring-Opening Enzyme

1.2 Other Identifiers

1.2.1 Enzyme Commission (EC) Number

1.2.2 GlyCosmos Gene

2 Proteins

2.1 Protein Function

Involved in riboflavin biosynthesis. Catalyzes both the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate and the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. RIBA2 and RIBA3 together are not able to complement the loss of function of RIBA1.

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 NLM Curated PubMed Citations

6.3 Gene-Chemical Co-Occurrences in Literature

6.4 Gene-Gene Co-Occurrences in Literature

6.5 Gene-Disease Co-Occurrences in Literature

7 Classification

7.1 MeSH Tree

8 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  7. NCBI Gene Expression Omnibus (GEO)
  8. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  9. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  10. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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