Abcb11 - ATP binding cassette subfamily B member 11 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; xenobiotic export from cell; and xenobiotic transmembrane transport. Located in Golgi membrane; intracellular canaliculus; and recycling endosome membrane. Used to study cholestasis. Biomarker of alcoholic hepatitis and cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).
- Bsep
- Spgp
- bile salt export pump
- ATP-binding cassette sub-family B member 11
- ATP-binding cassette, sub-family B (MDR/TAP), member 11
- ATP-binding cassette, subfamily B (MDR/TAP), member 11
- sister of P-glycoprotein
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PMID: 15901796, PMID: 16332456, PMID: 17082223, PMID: 18985798, PMID: 9545351). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PMID: 16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PMID: 15901796, PMID: 18245269).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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