MFP2 - multifunctional protein 2 (thale cress)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
Encodes a multifunctional protein. Involved in peroxisomal fatty acid beta oxidation. Loss-of-function mutant lacks hydroxyacyl-CoA dehydrogenase activity and have reduced levels of long-chain enoyl-CoA hydratase activity. The mutant has fewer but larger peroxisomes.
- ATMFP2
- F3E22.20
- MULTIFUNCTIONAL PROTEIN 2
- multifunctional protein 2
Involved in peroxisomal fatty acid beta-oxidation during seed germination. Possesses enoyl-CoA hydratase activity against long chain substrates (C14-C18) and 3-hydroxyacyl-CoA dehydrogenase activity against chains of variable sizes (C6-C18) (PMID: 10521521, PMID: 16507084, PMID: 20463021). Possesses 3-hydroxy-3-phenylpropionyl-CoA dehydrogenase activity and is involved in the peroxisomal beta-oxidation pathway for the biosynthesis of benzoic acid (BA). Required for the accumulation in seeds of substituted hydroxybenzoylated choline esters, which are BA-containing secondary metabolites (PMID: 24254312). Fatty acid beta-oxidation pathway in peroxisomes regulates gene silencing, histone acetylation and DNA methylation (PMID: 31064880).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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