Adcy2 - adenylate cyclase 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Located in membrane raft and plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2).
- AC2
- adenylate cyclase type 2
- ATP pyrophosphate-lyase 2
- adenylate cyclase 2 (brain)
- adenylate cyclase type II
- adenylyl cyclase 2
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PMID: 10427002, PMID: 11087399, PMID: 15591060, PMID: 16766715, PMID: 1719547, PMID: 19243146, PMID: 21596131, PMID: 22906005, PMID: 24363043, PMID: 7761832). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production (PMID: 24363043). Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (PMID: 22906005).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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