PLA2-ALPHA - Phospholipase A2 family protein (thale cress)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-31
Description
Encodes a secretory phospholipase A2 enzyme, which specifically hydrolyzes the sn-2 position of phospholipids. The enzyme has a preference towards linoleoyl acyl chain over palmitoyl acyl chain. It also has a slight preference for phosphatidylcholine over phosphatidylethanolamine.
- ATSPLA2-ALPHA
- PHOSPHOLIPASE A2-ALPHA
- Cytosolic Phospholipase A2 alpha
- Cytosolic Phospholipase A2 beta
- Cytosolic Phospholipase A2 delta
- Cytosolic Phospholipase A2 epsilon
- Cytosolic Phospholipase A2 gamma
- Group IV Cytosolic Phospholipase A2
- Group IVA Phospholipase A2
- Group IVA Phospholipases A2
- Group IVB Phospholipase A2
- Group IVB Phospholipases A2
- Group IVC Phospholipase A2
- Group IVC Phospholipases A2
- Group IVD Phospholipase A2
- Group IVD Phospholipases A2
- Group IVE Phospholipase A2
- Group IVE Phospholipases A2
- Group IVF Phospholipase A2
- Group IVF Phospholipases A2
- PLA(2)-IV
- PLA2-IV
- Phospholipase A(2)alpha
- Phospholipase A2 Group IVA
- Phospholipase A2 IV
- Phospholipase A2, Group IVB
- Phospholipase A2, Group IVC
- Phospholipase A2, Group IVD
- Phospholipase A2, Group IVE
- Phospholipase A2, Group IVF
- Phospholipase A2-alpha
- Phospholipase A2-beta
- Phospholipase A2-gamma
- Phospholipases A2, Group IV
- cPLA2-alpha
- cPLA2-gamma
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Modulates the trafficking of PIN proteins to the plasma membrane (PMID: 16140037, PMID: 20525850). Negatively regulates MYB30 transcriptional activity and hypersensitive response control (PMID: 20696912).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- PubChem
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- STRING: functional protein association networks
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