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PLA2-ALPHA - Phospholipase A2 family protein (thale cress)

Gene
Dates
  • Create:
    2016-09-14
  • Modify:
    2024-12-31
Description
Encodes a secretory phospholipase A2 enzyme, which specifically hydrolyzes the sn-2 position of phospholipids. The enzyme has a preference towards linoleoyl acyl chain over palmitoyl acyl chain. It also has a slight preference for phosphatidylcholine over phosphatidylethanolamine.

1 Names and Identifiers

1.1 Synonyms

  • ATSPLA2-ALPHA
  • PHOSPHOLIPASE A2-ALPHA

1.1.1 MeSH Entry Terms

  • Cytosolic Phospholipase A2 alpha
  • Cytosolic Phospholipase A2 beta
  • Cytosolic Phospholipase A2 delta
  • Cytosolic Phospholipase A2 epsilon
  • Cytosolic Phospholipase A2 gamma
  • Group IV Cytosolic Phospholipase A2
  • Group IVA Phospholipase A2
  • Group IVA Phospholipases A2
  • Group IVB Phospholipase A2
  • Group IVB Phospholipases A2
  • Group IVC Phospholipase A2
  • Group IVC Phospholipases A2
  • Group IVD Phospholipase A2
  • Group IVD Phospholipases A2
  • Group IVE Phospholipase A2
  • Group IVE Phospholipases A2
  • Group IVF Phospholipase A2
  • Group IVF Phospholipases A2
  • PLA(2)-IV
  • PLA2-IV
  • Phospholipase A(2)alpha
  • Phospholipase A2 Group IVA
  • Phospholipase A2 IV
  • Phospholipase A2, Group IVB
  • Phospholipase A2, Group IVC
  • Phospholipase A2, Group IVD
  • Phospholipase A2, Group IVE
  • Phospholipase A2, Group IVF
  • Phospholipase A2-alpha
  • Phospholipase A2-beta
  • Phospholipase A2-gamma
  • Phospholipases A2, Group IV
  • cPLA2-alpha
  • cPLA2-gamma

1.2 Other Identifiers

1.2.1 Enzyme Commission (EC) Number

1.2.2 GlyCosmos Gene

2 Proteins

2.1 Protein Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Modulates the trafficking of PIN proteins to the plasma membrane (PMID: 16140037, PMID: 20525850). Negatively regulates MYB30 transcriptional activity and hypersensitive response control (PMID: 20696912).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Expression

6 Literature

6.1 NLM Curated PubMed Citations

7 Classification

7.1 MeSH Tree

8 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  5. NCBI Gene Expression Omnibus (GEO)
  6. STRING: functional protein association networks
  7. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  8. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  9. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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