DNAJC5 - DnaJ heat shock protein family (Hsp40) member C5 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
Predicted to enable ATP-dependent protein binding activity. Predicted to be involved in chaperone-mediated protein folding and regulation of synaptic vesicle cycle. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in Golgi apparatus and plasma membrane. Implicated in neuronal ceroid lipofuscinosis 4.
The DNAJC5 gene provides instructions for making a protein called cysteine string protein alpha (CSPα). This protein is found near nerve cells in the brain, where it plays a role in the transmission of nerve impulses. Specifically, CSPα is part of a group (complex) of proteins that is found on the membrane of sac-like structures called synaptic vesicles. Synaptic vesicles are found close to the ends of nerve cells and contain chemical messengers that transmit signals from one nerve cell to another. CSPα is involved in recycling proteins that are involved in nerve impulse transmission by re-folding misshapen proteins so that they can be used in additional transmissions.
- CLN4
- CLN4B
- CSP
- DNAJC5A
- NCL
- mir-941-2
- mir-941-3
- mir-941-4
- mir-941-5
- dnaJ homolog subfamily C member 5
- DnaJ (Hsp40) homolog, subfamily C, member 5
- ceroid-lipofuscinosis neuronal protein 4
- cysteine string protein alpha
Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Alliance of Genome ResourcesLICENSEAll annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).https://www.alliancegenome.org/privacy-warranty-licensing
- MedlinePlus GeneticsLICENSETerms and conditions of use apply to all persons or organizations that publish or distribute content from the MedlinePlus website.https://medlineplus.gov/about/using/usingcontent/
- BioGRIDLICENSEThe MIT License (MIT); Copyright Mike Tyers Labhttps://wiki.thebiogrid.org/doku.php/terms_and_conditions
- STRING: functional protein association networks
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp
- Gene Curation Coalition (GenCC)LICENSEThe GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.https://thegencc.org/terms.htmlDNAJC5
- HUGO Gene Nomenclature Committee (HGNC)LICENSENo restrictions are imposed on access to, or use of, the data provided by the HGNC, which are provided to enhance knowledge and encourage progress in the scientific community.https://www.genenames.org/about/
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- NCBI Gene Expression Omnibus (GEO)
- NCBI MedGenLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- Online Mendelian Inheritance in Man (OMIM)LICENSEThe OMIM database is made available to the general public subject to certain restrictions.https://omim.org/help/copyright
- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licence
- PharmGKBLICENSEPharmGKB data are subject to the Creative Commons Attribution-ShareALike 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/).https://www.pharmgkb.org/page/policies
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/about
- RCSB Protein Data Bank (RCSB PDB)LICENSEData files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.https://www.rcsb.org/pages/policies
- Swiss Institute of Bioinformatics Bgee
- UniProtLICENSEWe have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.https://www.uniprot.org/help/license
- VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics ResourceLICENSEAll data on VEuPathDB websites are provided freely for public use.https://veupathdb.org/veupathdb/app/static-content/about.html
- Wikidata
- Gene Ontology (GO)LICENSEGene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)http://geneontology.org/docs/go-citation-policy/Biological Processhttp://www.geneontology.org/
- AlphaFold DBLICENSEAll of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.https://alphafold.ebi.ac.uk/faq
CONTENTS