EDC3 - enhancer of mRNA decapping 3 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]
Enables identical protein binding activity. Predicted to be involved in P-body assembly and deadenylation-independent decapping of nuclear-transcribed mRNA. Located in cytoplasmic ribonucleoprotein granule. Implicated in autosomal recessive intellectual developmental disorder 50.
- LSM16
- MRT50
- YJDC
- YJEFN2
- hYjeF_N2-15q23
- enhancer of mRNA-decapping protein 3
- LSM16 homolog (EDC3, S. cerevisiae)
- enhancer of mRNA decapping 3 homolog
- yjeF N-terminal domain-containing protein 2
- yjeF domain containing
- yjeF domain-containing protein 1
Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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