An official website of the United States government

akr1a1b - aldo-keto reductase family 1, member A1b (aldehyde reductase) (zebrafish)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18
Description
Enables aldo-keto reductase (NADPH) activity. Involved in glucose homeostasis and regulation of gluconeogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).

1 Names and Identifiers

1.1 Synonyms

  • akr1a1
  • zgc:110225
  • aldo-keto reductase family 1 member A1-B
  • S-nitroso-CoA reductase
  • alcohol dehydrogenase [NADP(+)] B
  • alcohol dehydrogenase [NADP+] B
  • aldehyde reductase-B
  • aldo-keto reductase family 1, member A1
  • scorR

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 Wikidata

1.2.5 ZFIN ID

3 Proteins

3.1 Protein Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (By similarity). Displays no reductase activity towards retinoids (By similarity).

3.2 Protein 3D Structures

3.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.3 Protein Targets

4 Interactions and Pathways

4.1 Chemical-Gene Interactions

4.2 Interactions

4.3 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

7.2 Gene-Chemical Co-Occurrences in Literature

7.3 Gene-Gene Co-Occurrences in Literature

7.4 Gene-Disease Co-Occurrences in Literature

8 Patents

9 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  5. NCBI Gene Expression Omnibus (GEO)
  6. STRING: functional protein association networks
  7. The Zebrafish Information Network (ZFIN)
    LICENSE
    ZFIN data and data annotations are licensed under a Creative Commons Attribution 4.0 International License
    https://zfin.atlassian.net/wiki/spaces/general/pages/1942160112/WARRANTY+AND+LIABILITY+DISCLAIMER+OWNERSHIP+AND+LIMITS+ON+USE
  8. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  9. Wikidata
  10. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  11. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
CONTENTS