akr1a1b - aldo-keto reductase family 1, member A1b (aldehyde reductase) (zebrafish)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables aldo-keto reductase (NADPH) activity. Involved in glucose homeostasis and regulation of gluconeogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).
- akr1a1
- zgc:110225
- aldo-keto reductase family 1 member A1-B
- S-nitroso-CoA reductase
- alcohol dehydrogenase [NADP(+)] B
- alcohol dehydrogenase [NADP+] B
- aldehyde reductase-B
- aldo-keto reductase family 1, member A1
- scorR
- AKR1A1 (human)
- AKR1A1 (black-footed ferret)
- AKR1A1 (European mink)
- AKR1A1 (Ahaetulla prasina)
- AKR1A1 (red-backed fairy wren)
- AKR1A1 (Oenanthe melanoleuca)
- AKR1A1 (Chinese forest musk deer)
- AKR1A1 (raccoon dog)
- AKR1A1 (Leopard gecko)
- AKR1A1 (Pteronotus mesoamericanus)
- AKR1A1 (black-legged kittiwake)
- AKR1A1 (Aeolian wall lizard)
- AKR1A1 (graceful crag lizard)
- AKR1A1 (lesser prairie-chicken)
- AKR1A1 (takin)
- AKR1A1 (yellow-footed antechinus)
- AKR1A1 (Macaca thibetana thibetana)
- AKR1A1 (Northern goshawk)
- AKR1A1 (snow leopard)
- AKR1A1 (rock ptarmigan)
- AKR1A1 (Loggerhead turtle)
- AKR1A1 (Sphaerodactylus townsendi)
- AKR1A1 (Eurasian river otter)
- AKR1A1 (bobcat)
- AKR1A1 (greater spear-nosed bat)
- AKR1A1 (American black bear)
- AKR1A1 (Ring-tailed lemur)
- AKR1A1 (Agile Gracile Mouse Opossum)
- AKR1A1 (Komodo dragon)
- AKR1A1 (Asiatic toad)
- AKR1A1 (American mink)
- AKR1A1 (leopard cat)
- AKR1A1 (wapiti)
- AKR1A1 (fence lizard)
- AKR1A1 (Arctic fox)
- AKR1A1 (rufous-necked snowfinch)
- AKR1A1 (white-rumped snowfinch)
- AKR1A1 (jaguarundi)
- AKR1A1 (common toad)
- AKR1A1 (common frog)
- AKR1A1 (scimitar-horned oryx)
- AKR1A1 (Barn swallow)
- AKR1A1 (large flying fox)
- AKR1A1 (Eurasian tree sparrow)
- AKR1A1 (Reeves's turtle)
- AKR1A1 (Tiger rattlesnake)
- AKR1A1 (striped hyena)
- AKR1A1 (leatherback sea turtle)
- AKR1A1 (Iberian mole)
- AKR1A1 (Jamaican fruit-eating bat)
- AKR1A1 (Sturnira hondurensis)
- AKR1A1 (Kuhl's pipistrelle)
- AKR1A1 (Myotis myotis)
- AKR1A1 (Pallas's mastiff bat)
- AKR1A1 (dingo)
- AKR1A1 (black swan)
- AKR1A1 (common lizard)
- AKR1A1 (Southern elephant seal)
- AKR1A1 (Trachemys scripta elegans)
- AKR1A1 (Pantherophis guttatus)
- AKR1A1 (Gaboon caecilian)
- AKR1A1 (Francois's langur)
- AKR1A1 (greater horseshoe bat)
- AKR1A1 (sea lamprey)
- AKR1A1 (Abingdon island giant tortoise)
- AKR1A1 (vaquita)
- AKR1A1 (tufted duck)
- AKR1A1 (silvery gibbon)
- AKR1A1 (ring-necked pheasant)
- AKR1A1 (Kakapo)
- AKR1A1 (Aquila chrysaetos chrysaetos)
- AKR1A1 (Common wall lizard)
- AKR1A1 (pale spear-nosed bat)
- AKR1A1 (Steller sea lion)
- AKR1A1 (willow flycatcher)
- AKR1A1 (California sea lion)
- AKR1A1 (burrowing owl)
- AKR1A1 (eastern brown snake)
- AKR1A1 (mainland tiger snake)
- AKR1A1 (brown bear)
- AKR1A1 (emu)
- AKR1A1 (Okarito brown kiwi)
- AKR1A1 (Nothoprocta perdicaria)
- AKR1A1 (red fox)
- AKR1A1 (puma)
- AKR1A1 (gelada)
- AKR1A1 (Yangtze finless porpoise)
- AKR1A1 (common vampire bat)
- AKR1A1 (blue tit)
- AKR1A1 (Ugandan red Colobus)
- AKR1A1 (beluga whale)
- AKR1A1 (Hawaiian monk seal)
- AKR1A1 (white-rumped munia)
- AKR1A1 (helmeted guineafowl)
- AKR1A1 (koala)
- AKR1A1 (central bearded dragon)
- AKR1A1 (zebu cattle)
- AKR1A1 (great roundleaf bat)
- AKR1A1 (Australian saltwater crocodile)
- AKR1A1 (Gharial)
- AKR1A1 (leopard)
- AKR1A1 (Nanorana parkeri)
- AKR1A1 (black snub-nosed monkey)
- AKR1A1 (Malayan pangolin)
- AKR1A1 (Panamanian white-faced capuchin)
- AKR1A1 (Miniopterus natalensis)
- AKR1A1 (Egyptian rousette)
- AKR1A1 (Japanese quail)
- AKR1A1 (Taiwan habu)
- AKR1A1 (Great Tit)
- AKR1A1 (Gekko japonicus)
- AKR1A1 (cheetah)
- AKR1A1 (Common starling)
- AKR1A1 (ass)
- AKR1A1 (Thamnophis sirtalis)
- AKR1A1 (North Island brown kiwi)
- AKR1A1 (Swan goose)
- AKR1A1 (gray mouse lemur)
- AKR1A1 (Coquerel's sifaka)
- AKR1A1 (sooty mangabey)
- AKR1A1 (drill)
- AKR1A1 (Colobus angolensis palliatus)
- AKR1A1 (pig-tailed macaque)
- AKR1A1 (large flying fox)
- AKR1A1 (Arabian camel)
- AKR1A1 (Bactrian camel)
- AKR1A1 (Bison bison bison)
- AKR1A1 (bald eagle)
- AKR1A1 (Corvus cornix cornix)
- AKR1A1 (golden snub-nosed monkey)
- AKR1A1 (East African grey crowned-crane)
- AKR1A1 (White-tailed tropicbird)
- AKR1A1 (white-throated tinamou)
- AKR1A1 (brown roatelo)
- AKR1A1 (chuck-will's-widow)
- AKR1A1 (sunbittern)
- AKR1A1 (Buceros rhinoceros silvestris)
- AKR1A1 (Macqueen's bustard)
- AKR1A1 (yellow-throated sandgrouse)
- AKR1A1 (Kea)
- AKR1A1 (chimney swift)
- AKR1A1 (red-crested turaco)
- AKR1A1 (common barn owl)
- AKR1A1 (cuckoo roller)
- AKR1A1 (hoatzin)
- AKR1A1 (white-tailed eagle)
- AKR1A1 (Downy woodpecker)
- AKR1A1 (killdeer)
- AKR1A1 (bar-tailed trogon)
- AKR1A1 (red-throated loon)
- AKR1A1 (Red-legged seriema)
- AKR1A1 (African ostrich)
- AKR1A1 (little egret)
- AKR1A1 (common cuckoo)
- AKR1A1 (Dalmatian pelican)
- AKR1A1 (crested ibis)
- AKR1A1 (Adelie penguin)
- AKR1A1 (emperor penguin)
- AKR1A1 (Common canary)
- AKR1A1 (rifleman)
- AKR1A1 (polar bear)
- AKR1A1 (American crow)
- AKR1A1 (Sunda flying lemur)
- AKR1A1 (Przewalski's horse)
- AKR1A1 (big brown bat)
- AKR1A1 (Philippine tarsier)
- AKR1A1 (green monkey)
- AKR1A1 (Yangtze River dolphin)
- AKR1A1 (Burmese python)
- AKR1A1 (minke whale)
- AKR1A1 (sperm whale)
- AKR1A1 (tiger)
- AKR1A1 (Green sea turtle)
- AKR1A1 (black flying fox)
- AKR1A1 (Myotis davidii)
- AKR1A1 (Weddell seal)
- AKR1A1 (American alligator)
- AKR1A1 (alpaca)
- AKR1A1 (Wild Bactrian camel)
- AKR1A1 (Chinese tree shrew)
- AKR1A1 (Chinese soft-shelled turtle)
- AKR1A1 (little brown bat)
- AKR1A1 (water buffalo)
- AKR1A1 (Chinese alligator)
- AKR1A1 (wild yak)
- AKR1A1 (Brandt's bat)
- AKR1A1 (goat)
- AKR1A1 (crab-eating macaque)
- AKR1A1 (Tibetan ground-tit)
- AKR1A1 (rock pigeon)
- AKR1A1 (white-throated sparrow)
- AKR1A1 (Saker falcon)
- AKR1A1 (medium ground-finch)
- Akr1a1 (long-tailed chinchilla)
- AKR1A1 (western painted turtle)
- AKR1A1 (peregrine falcon)
- AKR1A1 (Collared flycatcher)
- AKR1A1 (mallard)
- AKR1A1 (domestic ferret)
- AKR1A1 (small Madagascar hedgehog)
- AKR1A1 (European shrew)
- AKR1A1 (nine-banded armadillo)
- AKR1A1 (Pacific walrus)
- AKR1A1 (killer whale)
- AKR1A1 (western lowland gorilla)
- AKR1A1 (sheep)
- AKR1A1 (domestic cat)
- AKR1A1 (Bolivian squirrel monkey)
- AKR1A1 (olive baboon)
- AKR1A1 (pygmy chimpanzee)
- AKR1A1 (small-eared galago)
- AKR1A1 (Tasmanian devil)
- Akr1a1 (Chinese hamster)
- AKR1A1 (northern white-cheeked gibbon)
- AKR1A1 (turkey)
- AKR1A1 (giant panda)
- AKR1A1 (white-tufted-ear marmoset)
- AKR1A1 (zebra finch)
- AKR1A1 (Sumatran orangutan)
- AKR1A1 (platypus)
- AKR1A1 (horse)
- AKR1A1 (gray short-tailed opossum)
- AKR1A1 (chimpanzee)
- AKR1A1 (Rhesus monkey)
- AKR1A1 (domestic cattle)
- AKR1A1 (dog)
- akr1a1 (tropical clawed frog)
- AKR1A1 (chicken)
- AKR1A1 (pig)
- Akr1a1 (Norway rat)
- Akr1a1 (house mouse)
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (By similarity). Displays no reductase activity towards retinoids (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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