UGT2A3 - UDP glucuronosyltransferase family 2 member A3 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-26
Description
Enables glucuronosyltransferase activity. Involved in cellular glucuronidation. Predicted to be located in membrane.
- UDP-glucuronosyltransferase 2A3
- UDP glucuronosyltransferase 2 family, polypeptide A3
- UDPGT 2A3
- UGT2A3 (Macaca thibetana thibetana)
- UGT2A3 (Ring-tailed lemur)
- UGT2A3 (Francois's langur)
- UGT2A3 (pale spear-nosed bat)
- UGT2A3 (gelada)
- UGT2A3 (Ugandan red Colobus)
- UGT2A3 (black snub-nosed monkey)
- UGT2A3 (Panamanian white-faced capuchin)
- UGT2A3 (sooty mangabey)
- UGT2A3 (drill)
- UGT2A3 (Colobus angolensis palliatus)
- UGT2A3 (pig-tailed macaque)
- UGT2A3 (golden snub-nosed monkey)
- UGT2A3 (Sunda flying lemur)
- UGT2A3 (Philippine tarsier)
- UGT2A3 (Bolivian squirrel monkey)
- UGT2A3 (olive baboon)
- UGT2A3 (Rhesus monkey)
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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