Nr4a1 - nuclear receptor subfamily 4, group A, member 1 (Norway rat)
- Create:2016-09-14
- Modify:2025-01-18
- HMR
- Ngfi-b
- Nur77
- nuclear receptor subfamily 4 group A member 1
- Orphan nuclear receptor HMR
- immediate early gene transcription factor NGFI-B
- nerve growth factor induced protein I-B
- Early Response Protein NAK1
- NGFI-B Orphan Nuclear Receptor
- Nerve Growth Factor-inducible B Protein
- Nuclear Receptor NR4A1
- Nur77 Orphan Nuclear Receptor
- Orphan Nuclear Receptor HMR
- Orphan Nuclear Receptor NGFI-B
- Orphan Nuclear Receptor NR4A1
- Orphan Nuclear Receptor TR3
- TR3 Orphan Nuclear Receptor
Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PMID: 10331876). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (By similarity). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (By similarity). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (PMID: 8473329). Plays a role in the vascular response to injury (By similarity).
In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.
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