DAP3 - death associated protein 3 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Enables RNA binding activity. Predicted to be involved in apoptotic signaling pathway. Predicted to act upstream of or within apoptotic mitochondrial changes. Located in mitochondrion and nucleoplasm.
- DAP-3
- MRP-S29
- MRPS29
- S29mt
- bMRP-10
- mS29
- small ribosomal subunit protein mS29
- 28S ribosomal protein S29, mitochondrial
- ionizing radiation resistance conferring protein
- mitochondrial 28S ribosomal protein S29
- mitochondrial small ribosomal subunit protein mS29
Involved in mediating interferon-gamma-induced cell death.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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