Nln - neurolysin (metallopeptidase M3 family) (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Enables peptidase activity and peptide binding activity. Acts upstream of or within regulation of gluconeogenesis and regulation of skeletal muscle fiber differentiation. Located in plasma membrane. Orthologous to human NLN (neurolysin).
- 4930472G13Rik
- neurolysin, mitochondrial
- MEP
- microsomal endopeptidase
- mitochondrial oligopeptidase M
- neurotensin endopeptidase
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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