Tdrkh - tudor and KH domain containing protein (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Please note that currently there is no data available in PubChem associated with Tdrkh - tudor and KH domain containing protein (house mouse). However, annotations from external sources are available.
Predicted to enable RNA binding activity. Involved in several processes, including male meiotic nuclear division; piRNA processing; and spermatogenesis. Located in mitochondrion; pi-body; and piP-body. Is expressed in central nervous system; reproductive system; sensory organ; and urinary system. Orthologous to human TDRKH (tudor and KH domain containing).
- 2700091C21Rik
- Tdrd2
- tudor and KH domain-containing protein
- tudor domain-containing protein 2
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- STRING: functional protein association networks
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- Swiss Institute of Bioinformatics Bgee
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