TLE3 - TLE family member 3, transcriptional corepressor (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cold-induced thermogenesis. Located in nucleoplasm. Part of beta-catenin-TCF complex. Is active in nucleus.
- ESG
- ESG3
- GRG3
- HsT18976
- transducin-like enhancer protein 3
- enhancer of split groucho 3
- enhancer of split groucho-like protein 3
- transducin like enhancer of split 3
- transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
- transducin-like enhancer of split 3, homolog of Drosophila E(sp1)
Transcriptional corepressor that binds to a number of transcription factors (PMID: 28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PMID: 28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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