NKX2-1 - NK2 homeobox 1 (human)
- Create:2016-09-14
- Modify:2025-01-29
The NKX2-1 gene provides instructions for making a protein called homeobox protein Nkx-2.1, which is a member of the homeobox protein family. Homeobox proteins direct the formation of body structures during early embryonic development. Homeobox protein Nkx-2.1 is particularly involved in the development and function of the brain, lungs, and thyroid gland. The thyroid is a butterfly shaped gland in the lower neck that makes hormones to help regulate a wide variety of critical body functions, including growth and brain development.
Homeobox protein Nkx-2.1 functions as a transcription factor, which means it attaches to DNA and controls the activity (expression) of other genes. In the brain, homeobox protein Nkx-2.1 regulates genes that play a role in the development and movement (migration) of specialized nerve cells (neurons), called interneurons, to their proper location. Interneurons relay signals between other neurons. In the lungs, homeobox protein Nkx-2.1 controls development of lung structures and regulates the expression of surfactant genes, which provide instructions for producing surfactant proteins. Together with certain fats, these proteins form surfactant, which lines the lung tissue and makes breathing easy. In the thyroid gland, homeobox protein Nkx-2.1 controls genes that are critical in the production of thyroid hormones.
- BCH
- BHC
- NK-2
- NKX2.1
- NKX2A
- NMTC1
- T/EBP
- TEBP
- TITF1
- TTF-1
- TTF1
- homeobox protein Nkx-2.1
- NK-2 homolog A
- homeobox protein NK-2 homolog A
- thyroid nuclear factor 1
- thyroid transcription factor 1
- thyroid-specific enhancer-binding protein
- Homeobox Protein Nkx-2.1
- NK2 Homeobox 1 Protein
- TITF-1 Protein
- TITF1 Protein
- TTF-1 Thyroid Nuclear Factor
- Thyroid Transcription Factor 1
- Thyroid-Specific Enhancer-Binding Protein
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlThyroid Nuclear Factor 1https://meshb.nlm.nih.gov/record/ui?ui=D000074482
- Alliance of Genome ResourcesLICENSEAll annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).https://www.alliancegenome.org/privacy-warranty-licensing
- MedlinePlus GeneticsLICENSETerms and conditions of use apply to all persons or organizations that publish or distribute content from the MedlinePlus website.https://medlineplus.gov/about/using/usingcontent/
- BioGRIDLICENSEThe MIT License (MIT); Copyright Mike Tyers Labhttps://wiki.thebiogrid.org/doku.php/terms_and_conditions
- STRING: functional protein association networks
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp
- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licence
- Dependency Map (DepMap)
- Gene Curation Coalition (GenCC)LICENSEThe GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.https://thegencc.org/terms.htmlNKX2-1
- HUGO Gene Nomenclature Committee (HGNC)LICENSENo restrictions are imposed on access to, or use of, the data provided by the HGNC, which are provided to enhance knowledge and encourage progress in the scientific community.https://www.genenames.org/about/
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- NCBI Gene Expression Omnibus (GEO)
- NCBI MedGenLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- Online Mendelian Inheritance in Man (OMIM)LICENSEThe OMIM database is made available to the general public subject to certain restrictions.https://omim.org/help/copyright
- PharmGKBLICENSEPharmGKB data are subject to the Creative Commons Attribution-ShareALike 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/).https://www.pharmgkb.org/page/policies
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/about
- Swiss Institute of Bioinformatics Bgee
- UniProtLICENSEWe have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.https://www.uniprot.org/help/license
- VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics ResourceLICENSEAll data on VEuPathDB websites are provided freely for public use.https://veupathdb.org/veupathdb/app/static-content/about.html
- Wikidata
- Gene Ontology (GO)LICENSEGene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)http://geneontology.org/docs/go-citation-policy/Biological Processhttp://www.geneontology.org/
- AlphaFold DBLICENSEAll of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.https://alphafold.ebi.ac.uk/faq