Nudt12 - nudix hydrolase 12 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
Enables RNA NAD-cap (NMN-forming) hydrolase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in NAD-cap decapping; circadian regulation of gene expression; and mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in peroxisome. Is expressed in eye. Orthologous to human NUDT12 (nudix hydrolase 12).
- 0610016O18Rik
- NAD-capped RNA hydrolase NUDT12
- NADH pyrophosphatase NUDT12
- deNADding enzyme NUDT12
- nucleoside diphosphate-linked moiety X motif 12
- nudix (nucleoside diphosphate linked moiety X)-type motif 12
- nudix (nucleoside diphosphnudix (nucleoside diphosphate linked moiety X)-type motif 12ate linked moiety X)-type motif 12
- nudix motif 12
- peroxisomal NADH pyrophosphatase NUDT12
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PMID: 31101919, PMID: 32432673). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PMID: 31101919). Preferentially acts on NAD-capped transcripts in response to nutrient stress (PMID: 31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (By similarity). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (PMID: 31875550).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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