Trak1 - trafficking protein, kinesin binding 1 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables GABA receptor binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; organelle transport along microtubule; and positive regulation of axonogenesis. Predicted to be located in axonal growth cone; early endosome; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; spleen; and submandibular gland primordium. Used to study Stiff-Person syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to human TRAK1 (trafficking kinesin protein 1).
- 2310001H13Rik
- hyrt
- mKIAA1042
- trafficking kinesin-binding protein 1
- protein Milton
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (By similarity). Involved in mitochondrial motility (PMID: 24995978). When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (By similarity). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- Swiss Institute of Bioinformatics Bgee
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