Ndufa7 - NADH:ubiquinone oxidoreductase subunit A7 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. Complex I has been biochemically separated into four fractions. The bovine ortholog of this protein has been reported to be part of the I-lambda fraction, which forms the extrinsic globular domain. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. Pseudogenes of this gene are located on chromosomes 7 and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and respiratory system. Orthologous to human NDUFA7 (NADH:ubiquinone oxidoreductase subunit A7).
- 14.5kDa
- 2400007M02Rik
- CI-B14.5a
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
- NADH-ubiquinone oxidoreductase subunit B14.5a
- complex I-B14.5a
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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