SNAPC4 - small nuclear RNA activating complex polypeptide 4 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-27
Description
This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016]
Enables DNA binding activity; RNA polymerase II general transcription initiation factor activity; and RNA polymerase III general transcription initiation factor activity. Involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Part of snRNA-activating protein complex.
- NEDRSO
- PTFalpha
- SNAP190
- snRNA-activating protein complex subunit 4
- PSE-binding factor subunit alpha
- PTF subunit alpha
- SNAPc 190 kDa subunit
- SNAPc subunit 4
- proximal sequence element-binding transcription factor subunit alpha
- snRNA-activating protein complex 190 kDa subunit
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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