Aqp9 - aquaporin 9 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Enables several functions, including nucleobase transmembrane transporter activity; urea transmembrane transporter activity; and water channel activity. Involved in several processes, including canalicular bile acid transport; nucleobase transport; and response to pain. Located in basolateral plasma membrane. Orthologous to human AQP9 (aquaporin 9).
- aquaporin-9
- AQP-9
- aquaglyceroporin-9
- neutral solute channel aquaporin 9
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PMID: 10205677, PMID: 9733774). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PMID: 9733774). AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PMID: 11972053). It is also permeable to H2O2 in vivo (By similarity). Could also be permeable to ammonium (PMID: 15988592).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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