CREB3L2 - cAMP responsive element binding protein 3 like 2 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Enables cAMP response element binding activity. Involved in positive regulation of DNA-templated transcription and response to endoplasmic reticulum stress. Located in endoplasmic reticulum and nucleoplasm.
- BBF2H7
- cyclic AMP-responsive element-binding protein 3-like protein 2
- B-ZIB transcription factor
- BBF2 human homolog on chromosome 7
- FUS/BBF2H7 protein
- TCAG_1951439
- basic transcription factor 2
- cAMP-responsive element-binding protein 3-like protein 2
- BTF2 Transcription Factor
- Basic Transcription Factor 2
- TFIIH Transcription Factor
- Transcription Factor BTF2
- Transcription Factor IIH
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PMID: 17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PMID: 17178827).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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