Entpd2 - ectonucleoside triphosphate diphosphohydrolase 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to auditory stimulus. Located in cell body; cell projection membrane; and cell surface. Biomarker of hypertension. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2).
- Cd39l1
- NTPDase2
- CD39 antigen-like 1
- NTPDase 2
- ecto-ATP diphosphohydrolase 2
- ecto-ATPDase 2
- ecto-ATPase 2
- nucleoside triphosphate diphosphohydrolase 2
- testicular ecto-ATPase
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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