Nmu - neuromedin U (Norway rat)
- Create:2016-09-14
- Modify:2025-01-18
- neuromedin-U
- neuromedin U precursor-related peptide/neuromedin U preproprotein
Ligand for receptors NMUR1 and NMUR2 (PMID: 28874765). Receptor-binding is very tight if not irreversible and triggers an increase in the cytosolic Ca(2+) concentration (PMID: 28874765). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In rat, NMU stimulates contractions of stomach circular muscle.
Does not function as a ligand for either NMUR1 or NMUR2 (PMID: 28874765). Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36 (PMID: 28874765).
Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
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