Ugt2a1 - UDP glucuronosyltransferase family 2 member A1 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Predicted to enable glucuronosyltransferase activity. Predicted to be involved in bile acid metabolic process; cellular glucuronidation; and sensory perception of chemical stimulus. Predicted to be located in membrane. Orthologous to human UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus).
- Ugt2a1p
- UDP-glucuronosyltransferase 2A1
- UDP glucuronosyltransferase 2 family, polypeptide A1
- UDP glycosyltransferase 2 family, polypeptide A1
- UDPGT 2A1
- UGT-OLF
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterones) and estrogens (estradiol and estriol). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction.
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