Fhl2 - four and a half LIM domains 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Predicted to enable bHLH transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of calcineurin-NFAT signaling cascade. Located in M band and Z disc. Orthologous to human FHL2 (four and a half LIM domains 2).
- SLIM 3
- four and a half LIM domains protein 2
- LIM domain protein DRAL
- skeletal muscle LIM-protein 3
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PMID: 22851699).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- STRING: functional protein association networks
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- Swiss Institute of Bioinformatics Bgee
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