S100A6 - S100 calcium binding protein A6 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
The protein encoded by the S100A6 gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Enables several functions, including S100 protein binding activity; protein homodimerization activity; and tropomyosin binding activity. Predicted to be involved in cellular response to virus. Located in several cellular components, including cytoplasmic side of plasma membrane; perinuclear region of cytoplasm; and ruffle.
- 2A9
- 5B10
- CABP
- CACY
- PRA
- S10A6
- protein S100-A6
- MLN 4
- calcyclin
- growth factor-inducible protein 2A9
- prolactin receptor-associated protein
- Calcyclin
- S100A6 Protein
- S100-A6 Protein
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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