e2f8 - E2F transcription factor 8 (zebrafish)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-18
Description
Enables DNA binding activity and DNA-binding transcription factor activity. Involved in positive regulation of transcription by RNA polymerase II and sprouting angiogenesis. Acts upstream of or within lymphangiogenesis; motor neuron axon guidance; and negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including axis; caudal vein plexus; eye; liver; and proliferative region. Orthologous to human E2F8 (E2F transcription factor 8).
- im:7149356
- si:ch211-215h6.2
- wu:fc06b06
- transcription factor E2F8
- E2F family member 8
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- Swiss Institute of Bioinformatics Bgee
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