Nudt3 - nudix hydrolase 3 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity and 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity. Involved in RNA decapping. Is active in glutamatergic synapse. Orthologous to human NUDT3 (nudix hydrolase 3).
- 1110011B09Rik
- Dipp
- Dipp1
- diphosphoinositol polyphosphate phosphohydrolase 1
- DIPP-1
- ap6A hydrolase
- diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1
- diadenosine hexaphosphate hydrolase
- endopolyphosphatase
- m7GpppN-mRNA hydrolase
- m7GpppX diphosphatase
- nudix (nucleoside diphosphate linked moiety X)-type motif 3
- nudix (nucleotide diphosphate linked moiety X)-type motif 3
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PMID: 15212765). InsP6 (inositol hexakisphosphate) is not a substrate (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (By similarity). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (By similarity). Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Acts as a negative regulator of the ERK1/2 pathway (PMID: 15212765). Acts as a decapping enzyme that can hydrolyze both monomethylated and unmethylated capped RNAs (PMID: 23353937). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (PMID: 23353937). Modulates the stability of a subset of mRNAs implicated in cell motility (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (By similarity). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions (By similarity). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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