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Slc40a1 - solute carrier family 40 (iron-regulated transporter), member 1 (house mouse)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-29
Description
Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane and multicellular organismal-level iron ion homeostasis. Acts upstream of or within several processes, including iron ion transmembrane transport; positive regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1).

1 Names and Identifiers

1.1 Synonyms

  • Dusg
  • Fpn1
  • IREG1
  • MTP
  • MTP1
  • Ol5
  • Pcm
  • Slc11a3
  • Slc39a1
  • ferroportin
  • solute carrier family 40 member 1
  • SLC11A3 iron transporter
  • duodenal-specific
  • ferroportin 1
  • ferroportin1
  • iron-regulated transporter 1
  • metal transporter protein 1
  • metal transporting protein 1
  • polycythaemia
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
  • solute carrier family 39 (iron-regulated transporter), member 1

1.1.1 MeSH Entry Terms

  • Ferroportin1 Protein
  • Ferroportin Protein 1
  • Metal Transporting Protein 1
  • SLC40A1 Protein
  • Solute Carrier Family 40 (iron-regulated transporter), Member 1

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 MGI ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

3 Proteins

3.1 Protein Function

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PMID: 16054062, PMID: 30213870). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (PMID: 16054062, PMID: 30213870). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity).

3.2 Protein 3D Structures

3.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.3 Protein Targets

4 BioAssays

4.1 RNAi BioAssays

5 Interactions and Pathways

5.1 Chemical-Gene Interactions

5.2 Interactions

5.3 Pathways

6 Biochemical Reactions

7 Expression

8 Literature

8.1 Consolidated References

8.2 NLM Curated PubMed Citations

8.3 Gene-Chemical Co-Occurrences in Literature

8.4 Gene-Gene Co-Occurrences in Literature

8.5 Gene-Disease Co-Occurrences in Literature

9 Patents

9.1 Gene-Chemical Co-Occurrences in Patents

9.2 Gene-Gene Co-Occurrences in Patents

9.3 Gene-Disease Co-Occurrences in Patents

10 Classification

10.1 MeSH Tree

10.2 Gene Ontology: Biological Process

10.3 Gene Ontology: Cellular Component

10.4 Gene Ontology: Molecular Function

10.5 IUPHAR / BPS Guide to PHARMACOLOGY Target Classification

10.6 ChEMBL Target Tree

11 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. IUPHAR/BPS Guide to PHARMACOLOGY
    LICENSE
    The Guide to PHARMACOLOGY database is licensed under the Open Data Commons Open Database License (ODbL) https://opendatacommons.org/licenses/odbl/. Its contents are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-sa/4.0/)
    https://www.guidetopharmacology.org/about.jsp#license
    Guide to Pharmacology Target Classification
    https://www.guidetopharmacology.org/targets.jsp
  6. Mouse Genome Informatics (MGI)
    LICENSE
    MGI data and annotations are licensed under a Creative Commons Attribution 4.0 International License (CC-BY).
    https://www.informatics.jax.org/mgihome/other/copyright.shtml
  7. NCBI Gene Expression Omnibus (GEO)
  8. STRING: functional protein association networks
  9. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  10. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  11. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  12. Wikidata
  13. ChEMBL
    LICENSE
    Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).
    http://www.ebi.ac.uk/Information/termsofuse.html
  14. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  15. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  16. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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