Slc40a1 - solute carrier family 40 (iron-regulated transporter), member 1 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane and multicellular organismal-level iron ion homeostasis. Acts upstream of or within several processes, including iron ion transmembrane transport; positive regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1).
- Dusg
- Fpn1
- IREG1
- MTP
- MTP1
- Ol5
- Pcm
- Slc11a3
- Slc39a1
- ferroportin
- solute carrier family 40 member 1
- SLC11A3 iron transporter
- duodenal-specific
- ferroportin 1
- ferroportin1
- iron-regulated transporter 1
- metal transporter protein 1
- metal transporting protein 1
- polycythaemia
- solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
- solute carrier family 39 (iron-regulated transporter), member 1
- Ferroportin1 Protein
- Ferroportin Protein 1
- Metal Transporting Protein 1
- SLC40A1 Protein
- Solute Carrier Family 40 (iron-regulated transporter), Member 1
Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PMID: 16054062, PMID: 30213870). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (PMID: 16054062, PMID: 30213870). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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