Roc1b - Regulator of cullins 1b (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-26
Description
Enables cullin family protein binding activity and ubiquitin protein ligase activity. Involved in lipid storage and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. Is expressed in organism and wing disc.
- BcDNA:AT21612
- CG16988
- Dmel\CG16988
- ROC1B
- ROC1b
- ROC2
- Roc
- Roc2
- dRoc1b
- roc1b
- regulator of cullins 1b
- CG16988-PA
- Roc1b-PA
Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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