PKD2 - polycystin 2, transient receptor potential cation channel (human)
- Create:2016-09-14
- Modify:2025-01-07
The PKD2 gene provides instructions for making a protein called polycystin-2. This protein is found in the kidneys before birth and in many adult tissues. Although its exact function is not well understood, polycystin-2 can be regulated by a larger, somewhat similar protein called polycystin-1.
Polycystin-2 likely functions as a channel spanning the cell membrane of kidney cells. In conjunction with polycystin-1, the channel transports positively charged atoms (ions), particularly calcium ions, into the cell. This influx of calcium ions triggers a cascade of chemical reactions inside the cell that may instruct the cell to undergo certain changes, such as maturing to take on specialized functions. Polycystin-1 and polycystin-2 likely work together to help regulate cell growth and division (proliferation), cell movement (migration), and interactions with other cells.
Polycystin-2 is also active in other parts of the cell, including cellular structures called primary cilia. Primary cilia are tiny, fingerlike projections that line the small tubes where urine is formed (renal tubules). Researchers believe that primary cilia sense the movement of fluid through these tubules, which appears to help maintain the tubules' size and structure. The interaction of polycystin-1 and polycystin-2 in renal tubules promotes the normal development and function of the kidneys.
- APKD2
- PC2
- PKD4
- Pc-2
- TRPP2
- polycystin-2
- autosomal dominant polycystic kidney disease type II protein
- polycystic kidney disease 2 (autosomal dominant)
- transient receptor potential cation channel subfamily P member 2
- PKD2 (black-footed ferret)
- PKD2 (European mink)
- PKD2 (Ahaetulla prasina)
- PKD2 (Oenanthe melanoleuca)
- PKD2 (Chinese forest musk deer)
- PKD2 (raccoon dog)
- PKD2 (Leopard gecko)
- PKD2 (Pteronotus mesoamericanus)
- PKD2 (black-legged kittiwake)
- PKD2 (Aeolian wall lizard)
- PKD2 (graceful crag lizard)
- PKD2 (lesser prairie-chicken)
- PKD2 (takin)
- PKD2 (yellow-footed antechinus)
- PKD2 (California condor)
- PKD2 (Macaca thibetana thibetana)
- PKD2 (Northern goshawk)
- PKD2 (snow leopard)
- PKD2 (rock ptarmigan)
- PKD2 (Loggerhead turtle)
- PKD2 (Sphaerodactylus townsendi)
- PKD2 (Eurasian river otter)
- PKD2 (bobcat)
- PKD2 (greater spear-nosed bat)
- PKD2 (American black bear)
- PKD2 (Ring-tailed lemur)
- PKD2 (Agile Gracile Mouse Opossum)
- PKD2 (Komodo dragon)
- PKD2 (Asiatic toad)
- PKD2 (American mink)
- PKD2 (leopard cat)
- PKD2 (wapiti)
- PKD2 (fence lizard)
- PKD2 (Arctic fox)
- PKD2 (rufous-necked snowfinch)
- PKD2 (white-rumped snowfinch)
- PKD2 (jaguarundi)
- PKD2 (common toad)
- PKD2 (common frog)
- PKD2 (scimitar-horned oryx)
- PKD2 (Barn swallow)
- PKD2 (large flying fox)
- PKD2 (Eurasian tree sparrow)
- PKD2 (Reeves's turtle)
- PKD2 (Tiger rattlesnake)
- PKD2 (striped hyena)
- PKD2 (leatherback sea turtle)
- PKD2 (Iberian mole)
- PKD2 (Jamaican fruit-eating bat)
- PKD2 (Sturnira hondurensis)
- PKD2 (Kuhl's pipistrelle)
- PKD2 (Myotis myotis)
- PKD2 (Pallas's mastiff bat)
- PKD2 (black swan)
- PKD2 (Southern elephant seal)
- PKD2 (Trachemys scripta elegans)
- PKD2 (Pantherophis guttatus)
- PKD2 (Gaboon caecilian)
- PKD2 (Francois's langur)
- PKD2 (greater horseshoe bat)
- PKD2 (Abingdon island giant tortoise)
- PKD2 (vaquita)
- PKD2 (tufted duck)
- PKD2 (silvery gibbon)
- PKD2 (ring-necked pheasant)
- PKD2 (Kakapo)
- PKD2 (Microcaecilia unicolor)
- PKD2 (Aquila chrysaetos chrysaetos)
- PKD2 (Common wall lizard)
- PKD2 (pale spear-nosed bat)
- PKD2 (Steller sea lion)
- PKD2 (willow flycatcher)
- PKD2 (California sea lion)
- PKD2 (burrowing owl)
- PKD2 (eastern brown snake)
- PKD2 (mainland tiger snake)
- PKD2 (brown bear)
- PKD2 (emu)
- PKD2 (Okarito brown kiwi)
- PKD2 (Nothoprocta perdicaria)
- PKD2 (red fox)
- PKD2 (puma)
- PKD2 (dingo)
- PKD2 (gelada)
- PKD2 (Yangtze finless porpoise)
- PKD2 (common vampire bat)
- PKD2 (blue tit)
- PKD2 (Ugandan red Colobus)
- PKD2 (beluga whale)
- PKD2 (Hawaiian monk seal)
- PKD2 (white-rumped munia)
- PKD2 (helmeted guineafowl)
- PKD2 (koala)
- PKD2 (central bearded dragon)
- PKD2 (zebu cattle)
- PKD2 (great roundleaf bat)
- PKD2 (Australian saltwater crocodile)
- PKD2 (Gharial)
- PKD2 (leopard)
- PKD2 (Nanorana parkeri)
- PKD2 (black snub-nosed monkey)
- PKD2 (Malayan pangolin)
- PKD2 (Panamanian white-faced capuchin)
- PKD2 (Miniopterus natalensis)
- PKD2 (Egyptian rousette)
- PKD2 (Japanese quail)
- PKD2 (Great Tit)
- PKD2 (Gekko japonicus)
- PKD2 (cheetah)
- PKD2 (Common starling)
- PKD2 (ass)
- PKD2 (Thamnophis sirtalis)
- PKD2 (North Island brown kiwi)
- PKD2 (Swan goose)
- PKD2 (gray mouse lemur)
- PKD2 (Coquerel's sifaka)
- PKD2 (sooty mangabey)
- PKD2 (drill)
- PKD2 (Colobus angolensis palliatus)
- PKD2 (pig-tailed macaque)
- PKD2 (Arabian camel)
- PKD2 (Bactrian camel)
- PKD2 (Bison bison bison)
- PKD2 (bald eagle)
- PKD2 (Corvus cornix cornix)
- PKD2 (golden snub-nosed monkey)
- PKD2 (East African grey crowned-crane)
- PKD2 (White-tailed tropicbird)
- PKD2 (white-throated tinamou)
- PKD2 (speckled mousebird)
- PKD2 (brown roatelo)
- PKD2 (chuck-will's-widow)
- PKD2 (sunbittern)
- PKD2 (Buceros rhinoceros silvestris)
- PKD2 (Macqueen's bustard)
- PKD2 (yellow-throated sandgrouse)
- PKD2 (Kea)
- PKD2 (chimney swift)
- PKD2 (red-crested turaco)
- PKD2 (common barn owl)
- PKD2 (cuckoo roller)
- PKD2 (hoatzin)
- PKD2 (white-tailed eagle)
- PKD2 (Downy woodpecker)
- PKD2 (killdeer)
- PKD2 (bar-tailed trogon)
- PKD2 (red-throated loon)
- PKD2 (Red-legged seriema)
- PKD2 (African ostrich)
- PKD2 (little egret)
- PKD2 (Northern fulmar)
- PKD2 (common cuckoo)
- PKD2 (great cormorant)
- PKD2 (crested ibis)
- PKD2 (Adelie penguin)
- PKD2 (emperor penguin)
- PKD2 (Common canary)
- PKD2 (rifleman)
- PKD2 (carmine bee-eater)
- PKD2 (polar bear)
- PKD2 (American crow)
- PKD2 (Sunda flying lemur)
- PKD2 (Przewalski's horse)
- PKD2 (big brown bat)
- PKD2 (Philippine tarsier)
- PKD2 (green monkey)
- PKD2 (Yangtze River dolphin)
- PKD2 (Burmese python)
- PKD2 (minke whale)
- PKD2 (sperm whale)
- PKD2 (tiger)
- PKD2 (Green sea turtle)
- PKD2 (black flying fox)
- PKD2 (Myotis davidii)
- PKD2 (Weddell seal)
- PKD2 (American alligator)
- PKD2 (alpaca)
- PKD2 (Wild Bactrian camel)
- PKD2 (Chinese tree shrew)
- PKD2 (Chinese soft-shelled turtle)
- PKD2 (little brown bat)
- PKD2 (water buffalo)
- PKD2 (Chinese alligator)
- PKD2 (coelacanth)
- PKD2 (wild yak)
- PKD2 (Brandt's bat)
- PKD2 (goat)
- PKD2 (crab-eating macaque)
- PKD2 (Tibetan ground-tit)
- PKD2 (rock pigeon)
- PKD2 (white-throated sparrow)
- PKD2 (Saker falcon)
- PKD2 (medium ground-finch)
- Pkd2 (long-tailed chinchilla)
- PKD2 (western painted turtle)
- PKD2 (peregrine falcon)
- PKD2 (Collared flycatcher)
- PKD2 (mallard)
- PKD2 (domestic ferret)
- PKD2 (small Madagascar hedgehog)
- PKD2 (European shrew)
- PKD2 (American pika)
- PKD2 (nine-banded armadillo)
- PKD2 (Pacific walrus)
- PKD2 (killer whale)
- PKD2 (western lowland gorilla)
- PKD2 (sheep)
- PKD2 (domestic cat)
- PKD2 (Bolivian squirrel monkey)
- PKD2 (olive baboon)
- PKD2 (pygmy chimpanzee)
- PKD2 (small-eared galago)
- PKD2 (Tasmanian devil)
- PKD2 (African savanna elephant)
- PKD2 (northern white-cheeked gibbon)
- PKD2 (giant panda)
- PKD2 (Sumatran orangutan)
- PKD2 (white-tufted-ear marmoset)
- PKD2 (zebra finch)
- pkd2 (Japanese medaka)
- PKD2 (platypus)
- PKD2 (horse)
- pkd2 (tropical clawed frog)
- PKD2 (gray short-tailed opossum)
- PKD2 (Rhesus monkey)
- PKD2 (pig)
- PKD2 (domestic cattle)
- Pkd2 (Norway rat)
- PKD2 (dog)
- PKD2 (chimpanzee)
- pkd2 (zebrafish)
- PKD2 (chicken)
- Pkd2 (house mouse)
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