SERPINI2 - serpin family I member 2 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Predicted to enable serine-type endopeptidase inhibitor activity. Located in extracellular exosome.
- MEPI
- PANCPIN
- PI14
- TSA2004
- serpin I2
- myoepithelium-derived serine protease inhibitor
- myoepithelium-derived serine proteinase inhibitor
- pancreas-specific protein TSA2004
- peptidase inhibitor 14
- protease inhibitor 14
- serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2
- serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
- serpin peptidase inhibitor, clade I (pancpin), member 2
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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