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NELL2 - neural EGFL like 2 (domestic cattle)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2024-12-13
Description
Please note that currently there is no data available in PubChem associated with NELL2 - neural EGFL like 2 (domestic cattle). However, annotations from external sources are available.

1 Names and Identifiers

1.1 Synonyms

  • protein kinase C-binding protein NELL2
  • NEL-like 2
  • NEL-like protein 2

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Bgee Gene ID

1.2.3 VEuPathDB ID

3 Proteins

3.1 Protein Function

Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functions as a repulsive guidance cue for commissural axons, helping to steer them across the spinal cord midline (By similarity). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).

Testicular luminal protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility.

3.2 Protein Targets

4 Literature

4.1 Gene-Chemical Co-Occurrences in Literature

4.2 Gene-Gene Co-Occurrences in Literature

4.3 Gene-Disease Co-Occurrences in Literature

5 Patents

5.1 Gene-Chemical Co-Occurrences in Patents

5.2 Gene-Gene Co-Occurrences in Patents

5.3 Gene-Disease Co-Occurrences in Patents

6 Information Sources

CONTENTS