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SMAD2 - SMAD family member 2 (domestic cattle)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-28

1 Names and Identifiers

1.1 Synonyms

  • mothers against decapentaplegic homolog 2
  • MAD homolog 2
  • SMAD 2
  • SMAD, mothers against DPP homolog 2
  • mothers against DPP homolog 2

1.2 Other Identifiers

1.2.1 Ensembl ID

3 Proteins

3.1 Protein Function

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).

3.2 Protein Targets

4 Interactions and Pathways

4.1 Pathways

5 Expression

6 Literature

6.1 Gene-Chemical Co-Occurrences in Literature

6.2 Gene-Gene Co-Occurrences in Literature

6.3 Gene-Disease Co-Occurrences in Literature

7 Patents

7.1 Gene-Chemical Co-Occurrences in Patents

7.2 Gene-Gene Co-Occurrences in Patents

7.3 Gene-Disease Co-Occurrences in Patents

8 Information Sources

CONTENTS