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PSMD11 - proteasome 26S subunit, non-ATPase 11 (domestic cattle)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-27

1 Names and Identifiers

1.1 Synonyms

  • 26S proteasome non-ATPase regulatory subunit 11
  • 26S proteasome regulatory subunit RPN6
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
  • proteasome 26S non-ATPase subunit 11

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Bgee Gene ID

1.2.3 VEuPathDB ID

3 Proteins

3.1 Protein Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

3.2 Protein Isoforms

Isoform
Isoform 1
UniProt ID
RefSeq Accession
Isoform
Isoform 2
UniProt ID
RefSeq Accession

3.3 Protein Targets

4 Interactions and Pathways

4.1 Pathways

5 Expression

6 Literature

6.1 Gene-Chemical Co-Occurrences in Literature

6.2 Gene-Gene Co-Occurrences in Literature

6.3 Gene-Disease Co-Occurrences in Literature

7 Patents

7.1 Gene-Chemical Co-Occurrences in Patents

7.2 Gene-Gene Co-Occurrences in Patents

7.3 Gene-Disease Co-Occurrences in Patents

8 Information Sources

CONTENTS