SERPINA10 - serpin family A member 10 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
The protein encoded by the SERPINA10 gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation and liver regeneration. Located in extracellular exosome. Implicated in thrombophilia.
- PZI
- ZPI
- protein Z-dependent protease inhibitor
- PZ-dependent protease inhibitor
- Protein-Z dependent proteinase inhibitor
- serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
- serpin A10
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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