RDH11 - retinol dehydrogenase 11 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde and retinoid metabolic process. Acts upstream of or within retinal metabolic process. Located in endoplasmic reticulum membrane.
- ARSDR1
- CGI82
- HCBP12
- MDT1
- PSDR1
- RALR1
- RDJCSS
- SCALD
- SDR7C1
- HCV core-binding protein HCBP12
- androgen-regulated short-chain dehydrogenase/reductase 1
- prostate short-chain dehydrogenase reductase 1
- retinal reductase 1
- retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
- short chain dehydrogenase/reductase family 7C, member 1
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PMID: 12036956, PMID: 12226107, PMID: 29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PMID: 15865448). Has no dehydrogenase activity towards steroid (PMID: 12036956, PMID: 12226107).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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