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EFNA1 - ephrin A1 (domestic cattle)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18
Description
Please note that currently there is no data available in PubChem associated with EFNA1 - ephrin A1 (domestic cattle). However, annotations from external sources are available.

1 Names and Identifiers

1.1 Synonyms

ephrin-A1

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Bgee Gene ID

1.2.3 GlyCosmos Gene

1.2.4 VEuPathDB ID

3 Proteins

3.1 Protein Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).

3.2 Protein Targets

4 Literature

4.1 Gene-Chemical Co-Occurrences in Literature

4.2 Gene-Gene Co-Occurrences in Literature

4.3 Gene-Disease Co-Occurrences in Literature

5 Patents

5.1 Gene-Chemical Co-Occurrences in Patents

5.2 Gene-Gene Co-Occurrences in Patents

5.3 Gene-Disease Co-Occurrences in Patents

6 Information Sources

CONTENTS