Gar1 - GAR1 ribonucleoprotein (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Involved in snoRNA guided rRNA pseudouridine synthesis. Part of box H/ACA snoRNP complex. Orthologous to human GAR1 (GAR1 ribonucleoprotein).
- Nola1
- H/ACA ribonucleoprotein complex subunit 1
- GAR1 homolog, ribonucleoprotein
- GAR1 ribonucleoprotein homolog
- nucleolar protein family A member 1
- nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)
- snoRNP protein GAR1
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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