l(2)dtl - lethal-(2)-denticleless (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-13
Description
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in mitotic G2 DNA damage checkpoint signaling and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in organism. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog).
- CG11295
- Cdt2
- DTL83
- Dmel\CG11295
- L2DTL
- cdt2
- CG11295-PA
- l(2)dtl-PA
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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