Ran - Ran (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables GTP binding activity. Involved in several processes, including microtubule cytoskeleton organization; nuclear pore complex assembly; and regulation of mitotic cell cycle. Located in cell cortex; mitotic spindle microtubule; and nucleus. Colocalizes with mitotic spindle. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family).
- AAF30287
- CG1404
- Dmel\CG1404
- Q9VZ23
- RAN
- RanGTP
- dran
- l(1)G0075
- ran
- ran10A
- CG1404-PA
- CG1404-PB
- CG1404-PC
- CG1404-PD
- Ran GTPase
- Ran-PA
- Ran-PB
- Ran-PC
- Ran-PD
- ran
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis (By similarity). GTP-bound Ran modulates both spindle and nuclear envelope assembly, supporting a role during mitosis (PMID: 12121620). During oogenesis, modulates formation of Nup358-containing granules and biogenesis of the nuclear pore complex probably by mediating the transport of their components along microtubules (PMID: 31626769).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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