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sls - sallimus (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18
Description
Enables actin binding activity. A structural constituent of muscle. Involved in several processes, including chromosome organization; muscle attachment; and striated muscle cell differentiation. Located in Z disc; condensed nuclear chromosome; and striated muscle myosin thick filament. Is expressed in several structures, including adult head; embryonic myoblast; embryonic/larval midgut primordium; ganglia; and muscle cell. Used to study myopathy.

1 Names and Identifiers

1.1 Synonyms

  • 0020/01
  • CG18242
  • CG18245
  • CG18857
  • CG1915
  • CT41299
  • D-Titin
  • D-titin
  • Dmel\CG1915
  • KZ
  • Ket
  • Kettin
  • MCP
  • SLS
  • Sls
  • TITIN
  • Titin
  • anon-CREST
  • d-titin
  • ket
  • kettin
  • l(3)62Ca
  • l(3)Ca
  • l(3)S002001
  • l(3)dre8
  • l(3)j1D7
  • l(3)rL182
  • sal
  • sam
  • sls/kettin
  • titin
  • CG1915-PA
  • CG1915-PD
  • CG1915-PP
  • CG1915-PQ
  • CG1915-PR
  • CG1915-PS
  • CG1915-PT
  • CG1915-PU
  • CG1915-PV
  • CG1915-PW
  • CG1915-PX
  • CG1915-PY
  • CG1915-PZ
  • D-Titin/Kettin
  • D-titan
  • D-titin
  • D-titin-KZ
  • dtitin
  • kettin
  • lethal (3) S002001
  • lethal(3)62Ca
  • mitotic chromosomal protein
  • salimus
  • sls-PA
  • sls-PD
  • sls-PP
  • sls-PQ
  • sls-PR
  • sls-PS
  • sls-PT
  • sls-PU
  • sls-PV
  • sls-PW
  • sls-PX
  • sls-PY
  • sls-PZ
  • titin

1.1.1 MeSH Entry Terms

  • M-Protein (muscle)
  • M-Line 185 kDa Protein
  • M-Band Proteins
  • Muscle M-Line Protein
  • Myomesin
  • Skelemins
  • Titin
  • Titin 1
  • Titin Kinase
  • Titin 2
  • alpha-Connectin
  • beta-Connectin

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 FlyBase ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

2 Proteins

2.1 Protein Function

Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

2.2 Protein Isoforms

Isoform
Isoform C
UniProt ID
RefSeq Accession
Isoform
Isoform A
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform D
UniProt ID
RefSeq Accession
Isoform
Isoform E
UniProt ID
RefSeq Accession

2.3 Protein Targets

3 BioAssays

3.1 RNAi BioAssays

4 Interactions and Pathways

4.1 Chemical-Gene Interactions

4.2 Interactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 NLM Curated PubMed Citations

6.3 Gene-Chemical Co-Occurrences in Literature

6.4 Gene-Gene Co-Occurrences in Literature

6.5 Gene-Disease Co-Occurrences in Literature

7 Classification

7.1 MeSH Tree

7.2 Gene Ontology: Biological Process

7.3 Gene Ontology: Cellular Component

7.4 Gene Ontology: Molecular Function

8 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  6. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  7. STRING: functional protein association networks
  8. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  9. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  10. NCBI Gene Expression Omnibus (GEO)
  11. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  12. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  13. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  14. Wikidata
  15. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
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